植物から始まるより美しい未来 ボタチュラルNMNシリーズ誕生!

The Botatural series plant-based NMN follows a rare fully integrated process, from cassava cultivation to NMN production. The cassava is grown on vast farms in Cambodia and Laos, contributing to poverty alleviation through local employment, and is bio-fermented using microorganisms.

Plant-based NMN supplement series supervised  by beauty dermatologists, combining wisdom and innovation, for those who live beautifully.

Dr. Maki Miyake, a leading expert in laser and anti-aging treatments.

He collaborated with Dr. Shoichiro Kaku, Director of Tokyo Ginza AL Clinic, registered dietitian Chisato Matsuhisa, and supplement advisor Toshiya Nomura to develop the plant-based NMN supplement series 「Botanatural NMN」.

NMN, a popular ingredient in advanced beauty care, is now offered in a more natural and powerful supplement series.

Director of Tokyo Ginza AL Clinic

Former Kyoto University Institute for Life and Medical Sciences

Associate Professor

Professor Shoichiro Sumi

Omotesando Cosmetic Dermatology

Vice Director

Dr. Maki Miyake


Registered Dietitian

Ms. Chisane Matsuhisa

Supplement Advisor

Mr. Toshiya Nomura


Bio NMN 30000 Sakura

Contents:72.0g(each tablet weighs 400mg)

180 capsules:Approximately 30-60 days supply(Recommended dosage:3-6 capsules per day)

Manufacturer's suggested retail price:¥200,000(excluding tax)

Bio NMN 18000 Sakura

Contents:50.4g(each tablet weighs 420mg)

120 capsules:Approximately 30 days supply (Recommended dosage:4 capsules per day)

Manufacturer's suggested retail price:¥120,000(excluding tax)


Bio NMN 30000 Red

Contents:72.9g(each tablet weighs 405mg)

180 capsules::Approximately 30-60 days supply(Recommended dosage:3-6 capsules per day) 

Manufacturer's suggested retail price:¥200,000(excluding tax)

Bio NMN 18000 Red

Contents:51g(each tablet weighs 425mg)

120 capsules:Approximately 30 days supply  (Recommended dosage:4 capsules per day)

Manufacturer's suggested retail price:¥120,000(excluding tax)


Bio NMN Granules 18000

Contents:36g(1200mg x 30 bottles)

One bottle per day

Manufacturer's suggested retail price:¥120,000(excluding tax)


"I personally take it, so I can confidently recommend it."

Botatural NMN is highly praised by beauty professionals.

"Since I personally use it, I want to share how amazing it is." Many beauty professionals are becoming Bio ambassadors, sharing its amazing benefits. You can also purchase it at partner beauty salons.

Beauty Counselor

Ms. Keiko Kato

With 22 years in the beauty industry, began as an esthetician and now serves as a counselor at a beauty clinic, guiding women achieve their beauty goals.

Kiginokaori Owner Esthetician

Ms. Kayo Tazunoki

An esthetic salon known for its use of organic ingredients harnessing the power of nature, combined with all-hand treatments to effortlessly bring out natural beauty.


clasika Esthetician

Ms. Sumi Oka

Professional esthetic salon specializing in addressing skin concerns such as aging, dryness, and pores. Targets the foundation of beauty.

eclat plus Owner Esthetician

Ms. Rie Takeda

Transitioning into esthetics by leveraging nursing experience in general hospitals and cosmetic dermatology, with a focus on true beauty and well-being.


MC Narrator

Ms. Mamiko Yamada

2015 Mrs. Japan Grand Prix finalist, actively working as a host, etiquette instructor, and commercial model, while sharing beauty tips on social media.

EPIdeRIZ Owner Esthetician

Ms. Junko Fukunaga

A results-driven diet salon dedicated to supporting women’s beauty and health with care, while enhancing their self-esteem.


Botanical NMN derived from cassava.It is safe and secure because the origin of raw materials is clear.

Only a few companies in the world are capable of integrated manufacturing, from cultivation of NMN raw material to NMN supplement products.

Thorough quality control enables stable and efficient production.

During the fermentation process, microorganisms have the ability to synthesize NMN from precursors such as NR while multiplying.During this process, conditions such as temperature, pH, and oxygen supply are tightly controlled and optimized to maximize the yield of NMN.

Compared to chemical synthesis methods, it is environmentally friendly, sustainable, and can be produced on a large scale.